Disease-like degeneration in neural transplants
نویسندگان
چکیده
منابع مشابه
Neural transplants in patients with Huntington's disease undergo disease-like neuronal degeneration.
The clinical evaluation of neural transplantation as a potential treatment for Huntington's disease (HD) was initiated in an attempt to replace lost neurons and improve patient outcomes. Two of 3 patients with HD reported here, who underwent neural transplantation containing striatal anlagen in the striatum a decade earlier, have demonstrated marginal and transient clinical benefits. Their brai...
متن کاملNo evidence for disease-like processes in fetal transplants.
On the back of recent reports showing Lewy body-like inclusions in a small percentage of transplanted dopamine neurons in Parkinson’s disease (PD) over a decade after transplantation, Cicchetti et al. (1) now speculate that fetal grafts in Huntington’s disease (HD) show a predisposition to diseaselike processes 10 years after transplantation. Several points should, however, be taken into consid...
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Histology compatible with minimal change glomerulonephritis and associated with nephrotic syndrome has been reported as an occasional curiosity post-renal transplantation. Focal segmental glomerulosclerosis (FSGS) has a recurrence rate of approximately 20%. Age <15 years, an aggressive clinical course of the original disease and diffuse mesangial proliferation on native biopsy, are considered p...
متن کاملNeural remodeling in retinal degeneration.
Mammalian retinal degenerations initiated by gene defects in rods, cones or the retinal pigmented epithelium (RPE) often trigger loss of the sensory retina, effectively leaving the neural retina deafferented. The neural retina responds to this challenge by remodeling, first by subtle changes in neuronal structure and later by large-scale reorganization. Retinal degenerations in the mammalian re...
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PURPOSE Early visual defects in degenerative diseases such as retinitis pigmentosa (RP) may arise from phased remodeling of the neural retina. The authors sought to explore the functional expression of ionotropic (iGluR) and group 3, type 6 metabotropic (mGluR6) glutamate receptors in late-stage photoreceptor degeneration. METHODS Excitation mapping with organic cations and computational mole...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2009
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0908449106